T Cell Abnormalities in Common Variable Immunodeficiency
نویسندگان
چکیده
1. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran 2. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran 3. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran 6. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 7. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
منابع مشابه
T-cell abnormalities in common variable immunodeficiency: the hidden defect
This review discusses how the T-cell compartment in common variable immunodeficiency is marked by the premature arrest in thymic output, leading to T-cell exhaustion and immune dysregulation. Although B cells have been the main focus of the disorder, ample experimental data suggest that T-cell abnormalities can be seen in a large proportion of Freiburg Group 1a patients and those suffering from...
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Background Common Variable Immunodeficiency (CVID) is the most common symptomatic primary antibody deficiency in clinical practice and it is characterized by hypogammaglobulinemia, increased susceptibility to infections, autoimmune diseases and malignancies. The pathogenesis of CVID is still not well established. Immunologic abnormalities found in CVID patients include defects in B cell differe...
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A three year old boy with delayed separation of the umbilical cord, recurrent pyogenic infections and common variable immundeficiency is presented. The immunoglobulin measurement was severely abnormal. To the best of our knowledge, the existance of leukocyte adhesion disorder together with common variable immunodeficiency (CYID) in a patient has not been reported prior to this study.
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